Its gotta be a Manticore then, The manticore (Early Middle Persian Martyaxwar) is a Persian legendary creature similar to the Egyptian sphinx. It has the body of a red lion, a human head with three rows of sharp teeth (like a shark), and a trumpet-like voice. Other aspects of the creature vary from story to story. It may be horned, winged, or both. The tail is that of either a dragon or a scorpion, and it may shoot poisonous spines to either paralyze or kill its victims. It devours its prey whole and leaves no clothes, bones, or possessions. I've never used one in a game, but I've always wanted to. I've often thought about running a campaign where the PC's come up against mythological creatures & aberrations. It may still yet happen. Just within Greek mythology alone, there is the Hyrda, the Medusa, Centaur's, Satyr's, etc
If I had to pick 2, the other would be a Drider, they are a awfully freaky, a total aberration. The drow look down upon them, treat them as slaves, which makes them very dangerous. Although you do tend to almost feel sorry for them. The entire Drow culture is rife with viciousness, Exploitation and blind religion, which makes for interesting role playing.
In the Dungeons and Dragons roleplaying game, a drider is an aberration that was formerly a drow (dark elf). Driders are centaur-like creatures in the game, appearing as drow from the waist up, with their lower portions replaced by the abdomen and legs of immense spiders. They are most commonly found in the Underdark.